Forsyth Institute Receives $20.7 to Fight Periodontal Disease

Forsyth Institute Receives $20.7 to Fight Periodontal Disease

The Forsyth Institute , the world’s leading independent, oral health research organization, has received $20.7 million to fight periodontal disease. Three related projects will study periodontal disease progression from microbiological, genetic, host immune response and clinical perspectives. This research, funded by the National Institute of Dental and Craniofacial Research (NIDCR), will take place over a four-year period. The ultimate goal is to gain an understanding of why people develop gum disease, how the disease progresses, how to predict active disease before it occurs, and ultimately, how therapies can be developed to improve periodontal and overall health.

According to the Forsyth Institute, forty percent of adults in the United States have some form of periodontal disease. It is one of the most common infectious diseases and, in its more severe forms, causes loss of the bone that supports the teeth. In addition, there are strong associations between periodontal disease and systemic diseases including diabetes, metabolic syndrome, cardiovascular disease, pre-term birth, and certain cancers.

Previous work at Forsyth has demonstrated that the progression of the disease is not continuous, but is episodic. Thus, to understand its pathogenesis, patients must be studied to identify sites in the mouth that are undergoing active disease progression, which is the focus of these studies.  The Forsyth projects, respectively led by Dr. Ricardo Teles, Director of the Center for Clinical and Translational Research; Dr. Bruce Paster, Head, Department of Molecular Genetics; and Dr. Jorge Frias-Lopez, Assistant Member of Staff, Department of Molecular Genetics, will examine clinical parameters, expression of host derived molecules, bacterial ecology, and bacterial gene expression during active disease. It will also seek to identify biomarkers in blood, saliva, and gingival crevicular fluid (a fluid that oozes from the gum margin) samples from 500 individuals, both with and without existing gum disease. The data gathered by Forsyth’s scientists as well as aliquots of the samples will be made available to the scientific community and will represent the largest available information base and depository of samples for periodontal disease.

“The knowledge developed through these three linked projects will provide unique and extraordinarily valuable insights into the periodontal disease process, as well as serve as a one of a kind resource to the scientific community,” said Philip Stashenko, President and CEO of The Forsyth Institute. “This work represents the multidisciplinary epitome of periodontal disease research. We may be able to finally lay a firm foundation to understand why periodontal disease progresses. It is extremely rare for three projects to receive awards linked to one clinical trial, and this support from NIDCR is a testament to the promise of this research.”

The three projects were funded due to the strength of each projects and the overall potential impact of the collaborative research. The Forsyth team will also work with four other oral health research centers around the country. The Michigan Center for Oral Health Research is the first clinical research partner. Four additional research facilities will join the project shortly.

Worried About Your Health? Visit Your Dentist More Often

The Oral Health/Heart Health Connection

Worried About Your Health? Visit Your Dentist More Often

A recent study published in the journal Health Economics revealed that regular dental check-ups could reduce the risk of serious medical conditions by a third.

The study, led by a University of California, Berkeley, researcher could give women a little extra motivation to visit their dentist more regularly. The study suggests that women who get dental care reduce their risk of heart attacks, stroke and other cardiovascular problems by at least one-third.

While the analysis, which used data from nearly 7,000 people ages 44-88 enrolled in the Health and Retirement Study, did not find a similar benefit for men, however, dental experts are still urging male patients to take good care of their teeth and gums.

The study compared people who went to the dentist during the two years leading up the study, with data relating to those who had not visited the dentist during the previous two years.

The findings add to a growing body of research linking oral and cardiovascular health.

“Many studies have found associations between dental care and cardiovascular disease, but our study is the first to show that general dental care leads to fewer heart attacks, strokes, and other adverse cardiovascular outcomes in a causal way,” said study lead author Timothy Brown, assistant adjunct professor of health policy and management at UC Berkeley’s School of Public Health.

The fact that men and women did not benefit equally from dental care did not completely surprise the researchers. “To my knowledge, previous studies in this area have found that the relationship between poor oral health and cardiovascular disease markers varies by gender, but none have examined differences between men and women with regard to actual cardiovascular disease events,” said Brown, who is also associate director of research at UC Berkeley’s Nicholas C. Petris Center on Health Care Markets & Consumer Welfare.

“We think the findings reflect differences in how men and women develop cardiovascular disease,” said study co-author Dr. Stephen Brown, a first-year obstetrician/gynecologist resident at the West Virginia University Charleston Division School of Medicine. “Other studies suggest that estrogen has a protective effect against heart disease because it helps prevent the development of atherosclerosis. It’s not until women hit menopause around age 50 to 55 that they start catching up with men.”

Study Shows Periodontal Disease Far More Common Than Previously Believed

Study Shows Periodontal Disease Far More Common Than Previously Believed

In a study published in the online edition of the Journal of Dental Research, researchers at the CDC and the American Academy of Periodontology announced that officials have underestimated the prevalence of gum disease in the United States by as much as 50 percent.

“This study shows that periodontal disease is a bigger problem than we all thought. It is a call to action for anyone who cares about his or her oral health,” Dr. Samuel Low, professor of periodontology at the University of Florida College of Dentistry and president of the American Academy of Periodontology, said in a news release from the organization.

Since periodontal disease is known to do more than just harm the gums, these findings are quite serious. Without treatment, periodontal disease can become a gateway for serious diseases like heart disease, stroke, diabetes, and impaired kidney health, among other things.

“Given what we know about the relationship between gum disease and other diseases, taking care of your oral health isn’t just about a pretty smile. It has bigger implications for overall health, and is therefore a more significant public health problem,” Low added.

Paul Eke of the U.S. Centers for Disease Control and Prevention and colleagues examined the mouths of more than 450 people older than 35 years of age, finding more cases of gum disease than previous studies had. Researchers postulated that previous studies had less stringent guidelines for periodontal disease.

“Not only should you take good care of your periodontal health with daily tooth brushing and flossing, you should expect to get a comprehensive periodontal evaluation every year,” Low said.

Asthma Not Linked to Tooth Decay

Asthma Not Linked to Tooth Decay

Contrary to what you may have heard before, there’s no link between asthma and tooth decay in children, according to a study that appeared in the September issue of the Journal of the American Dental Association.

The findings challenge some previous research suggesting that children with asthma may be more likely to develop cavities. These studies had suggested that children who use nebulizers to control their asthma may inadvertently increase their frequency of exposure to sugars because these nebulizers use fructose to deliver therapy. This increased frequency and amount of certain sugars consumed are major factors leading to cavities

For the new study, researchers analyzed 27 studies in papers published between 1976 and March 2010.

“We found little evidence to suggest that asthma causes tooth decay. In fact, the two largest studies we reviewed found that children with asthma appear to have fewer cavities than others. This may be because their parents are used to taking them to health-care providers, and routinely bring them to the dentist,” study author Gerardo Maupome, a professor of preventive and community dentistry at the Indiana University School of Dentistry, said in a university news release.

“The notion that there is a link between asthma and tooth decay may have its origin in anecdotal statements by emergency room workers who see children with poorly managed asthma. These children could also be more likely to have poorly managed dental conditions, and therefore tooth decay,” Maupome said. “It’s reasonable to believe that poor clinical management may be associated with both conditions, not the asthma that is causing the cavities.”

While not apparently associated, tooth decay and asthma are the two most prevalent chronic childhood diseases in the United States.